Article
Segregation analysis of 1,546 prostate cancer families in Finland shows recessive inheritance.
Human genetics - 1 Apr 2007
Pakkanen Sanna, Baffoe-Bonnie Agnes B, Matikainen Mika P, Koivisto Pasi A, Tammela Teuvo L J, Deshmukh Snehal, Ou Liang, Bailey-Wilson Joan E, Schleutker Johanna
Abstract excerpt
Prostate cancer (PCa) is the most frequently diagnosed cancer in men worldwide and is likely to be caused by a number of genes with different modes of inheritance, population frequencies and penetrance. The objective of this study was to assess the familial aggregation of PCa in a sample of 1,546 nuclear families ascertained through an affected father and diagnosed during 1988-1993, from the unique, founder...
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