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Article

Studies of the regulation and function of the Gs alpha gene Gnas using gene targeting technology.

Pharmacology & therapeutics - 1 Aug 2007

Weinstein Lee S, Xie Tao, Zhang Qing-Hong, Chen Min

Abstract excerpt

The heterotrimeric G protein alpha-subunit G(s)alpha is ubiquitously expressed and mediates receptor-stimulated intracellular cAMP generation. Its gene Gnas is a complex imprinted gene which uses alternative promoters and first exons to generate other gene products, including the G(s)alpha isoform XL alpha s and the chromogranin-like protein NESP55, which are specifically expressed from the paternal and maternal...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17588669
DOI: 10.1016/j.pharmthera.2007.03.013
PMCID: PMC2031856

Genes

GNAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Studies of the regulation and function of the Gs alpha gene Gnas using gene targeting technology.PMID 17588669Read ↗

Alternative Gnas gene products have opposite effects on glucose and lipid metabolism.Semantic proximity Read ↗

The Alternative Stimulatory G Protein α-Subunit XLαs Is a Critical Regulator of Energy and Glucose Metabolism and Sympathetic Nerve Activity in Adult MiceSemantic proximity Read ↗

Physiological dysfunctions associated with mutations of the imprinted Gnas locus.Semantic proximity Read ↗

The imprinted signaling protein XL alpha s is required for postnatal adaptation to feeding.Semantic proximity Read ↗

GNAS -Related Loss-of-Function Disorders and the Role of Imprinting.Semantic proximity Read ↗

Role of G(s)α in central regulation of energy and glucose metabolism.Semantic proximity Read ↗

The GNAS complex locus and human diseases associated with loss-of-function mutations or epimutations within this imprinted gene.Semantic proximity Read ↗

Gs(alpha) mutations and imprinting defects in human disease.Semantic proximity Read ↗

Physiological functions of the imprinted Gnas locus and its protein variants Galpha(s) and XLalpha(s) in human and mouse.Semantic proximity Read ↗

Effects of deficiency of the G protein Gsα on energy and glucose homeostasis.Semantic proximity Read ↗

The role of GNAS and other imprinted genes in the development of obesity.Semantic proximity Read ↗

An imprinted antisense transcript at the human GNAS1 locusSemantic proximity Read ↗

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