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Article

IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin.

PloS one - 2 Jun 2009

Khoshnan Ali, Ko Jan, Tescu Simona, Brundin Patrick, Patterson Paul H

Abstract excerpt

BACKGROUND: Proteolysis of huntingtin (Htt) plays a key role in the pathogenesis of Huntington's disease (HD). However, the environmental cues and signaling pathways that regulate Htt proteolysis are poorly understood. One stimulus may be the DNA damage that accumulates in neurons over time, and...

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Identifiers

PMID: 19488402
DOI: 10.1371/journal.pone.0005768
PMCID: PMC2685016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19488402-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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