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Article

IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin.

PloS one - 2 Jun 2009

Khoshnan Ali, Ko Jan, Tescu Simona, Brundin Patrick, Patterson Paul H

Abstract excerpt

BACKGROUND: Proteolysis of huntingtin (Htt) plays a key role in the pathogenesis of Huntington's disease (HD). However, the environmental cues and signaling pathways that regulate Htt proteolysis are poorly understood. One stimulus may be the DNA damage that accumulates in neurons over time, and the subsequent activation of signaling pathways such as those regulated by IkappaB kinase (IKK), which can influence...

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Identifiers

PMID: 19488402
DOI: 10.1371/journal.pone.0005768
PMCID: PMC2685016

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Source receipt: pubmed, retrieved 7 Sept 2026.

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