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Article

Downregulation of NF-kappaB signaling by mutant huntingtin proteins induces oxidative stress and cell death.

Cellular and molecular life sciences : CMLS - 1 Jun 2010

Reijonen Sami, Kukkonen Jyrki P, Hyrskyluoto Alise, Kivinen Jenny, Kairisalo Minna, Takei Nobuyuki, Lindholm Dan, Korhonen Laura

Abstract excerpt

Accumulation of abnormal proteins and endoplasmic reticulum stress accompany neurodegenerative diseases including Huntington's disease. We show that the expression of mutant huntingtin proteins with extended polyglutamine repeats differentially affected endoplasmic reticulum signaling cascades linked to the inositol-requiring enzyme-1 (IRE1) pathway. Thus, the p38 and c-Jun N-terminal kinase pathways were...

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Identifiers

PMID: 20232225
DOI: 10.1007/s00018-010-0305-y
PMCID: PMC11115952

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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