Article
Loss of function of 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduced sterol levels.
The Plant journal : for cell and molecular biology - 1 Mar 2004
Suzuki Masashi, Kamide Yukiko, Nagata Noriko, Seki Hikaru, Ohyama Kiyoshi, Kato Hisashi, Masuda Kazuo, Sato Shusei, Kato Tomohiko, Tabata Satoshi, Yoshida Shigeo, Muranaka Toshiya
Abstract excerpt
3-Hydroxy-3-methylglutaryl-CoA reductase (HMGR) catalyzes the first committed step in the cytosolic isoprenoid biosynthesis pathway in higher plants. To understand the contribution of HMGR to plant development, we isolated T-DNA insertion mutants for HMG1 and HMG2. The hmg1 and hmg2 mutants were both more sensitive than the wild type (WT) to lovastatin, an inhibitor of HMGR. The hmg2 mutant showed no visible...
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