Article
Enhanced seed phytosterol accumulation through expression of a modified HMG-CoA reductase.
Plant biotechnology journal - 1 Mar 2006
Hey Sandra J, Powers Stephen J, Beale Michael H, Hawkins Nathaniel D, Ward Jane L, Halford Nigel G
Abstract excerpt
The regulation of phytosterol biosynthesis in seeds is of interest to biotechnologists because of the efficacy of dietary phytosterols in reducing blood cholesterol in humans. Mevalonate synthesis via 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) is a key step in phytosterol biosynthesis. HMG-CoA reductase is inactivated by phosphorylation by SNF1-related protein kinase 1 (SnRK1). With the...
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