Expression of <i>p16</i>^<i>INK4a</i> as a biomarker of T‐cell aging in HIV‐infected patients prior to and during antiretroviral therapy

Abstract excerpt

The p16(INK4a) tumor suppressor gene is a mediator of cellular senescence and has been suggested to be a biomarker of 'molecular' age in several tissues including T cells. To determine the association of both active and suppressed HIV infection with T-cell aging, T-cell p16(INK4a) expression was compared between 60 HIV+ suppressed subjects, 23 HIV+ untreated subjects, and 18 contemporaneously collected...

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