Article
A generalizable hypothesis for the genetic architecture of disease: pleomorphic risk loci.
Human molecular genetics - 15 Oct 2011
Singleton Andrew, Hardy John
Abstract excerpt
The dominant and sometimes competing theories for the aetiology of complex human disease have been the common disease, common variant (CDCV) hypothesis, and the multiple rare variant (MRV) hypothesis. With the advent of genome wide association studies and of second-generation sequencing, we are fortunate in being able to test these ideas. The results to date suggest that these hypotheses are not mutually...
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