Article
A-type lamins and signaling: the PI 3-kinase/Akt pathway moves forward.
Journal of cellular physiology - 1 Sept 2009
Marmiroli Sandra, Bertacchini Jessika, Beretti Francesca, Cenni Vittoria, Guida Marianna, De Pol Anto, Maraldi Nadir M, Lattanzi Giovanna
Abstract excerpt
Lamin A/C is a nuclear lamina constituent mutated in a number of human inherited disorders collectively referred to as laminopathies. The occurrence and significance of lamin A/C interplay with signaling molecules is an old question, suggested by pioneer studies performed in vitro. However, this relevant question has remained substantially unanswered, until data obtained in cellular and organismal models of...
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