Article
A genome-wide association study identifies ITGA9 conferring risk of nasopharyngeal carcinoma.
Journal of human genetics - 1 Jul 2009
Ng Ching Ching, Yew Poh Yin, Puah Suat Moi, Krishnan Gopala, Yap Lee Fah, Teo Soo Hwang, Lim Paul Vey Hong, Govindaraju Selvaratnam, Ratnavelu Kananathan, Sam Choon Kook, Takahashi Atsushi, Kubo Michiaki, Kamatani Naoyuki, Nakamura Yusuke, Mushiroda Taisei
Abstract excerpt
To identify a gene(s) susceptible to nasopharyngeal carcinoma (NPC), we carried out a genome-wide association study (GWAS) through genotyping of more than 500,000 tag single-nucleotide polymorphisms (SNPs), using an initial sample set of 111 unrelated NPC patients and 260 controls of a Malaysian Chinese population. We further evaluated the top 200 SNPs showing the smallest P-values, using a replication sample set...
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