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Article

Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure.

Plant biotechnology journal - 1 May 2008

Strasser Richard, Stadlmann Johannes, Schähs Matthias, Stiegler Gabriela, Quendler Heribert, Mach Lukas, Glössl Josef, Weterings Koen, Pabst Martin, Steinkellner Herta

Abstract excerpt

A common argument against using plants as a production system for therapeutic proteins is their inability to perform authentic human N-glycosylation (i.e. the presence of beta1,2-xylosylation and core alpha1,3-fucosylation). In this study, RNA interference (RNAi) technology was used to obtain a targeted down-regulation of the endogenous beta1,2-xylosyltransferase (XylT) and alpha1,3-fucosyltransferase (FucT)...

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Identifiers

PMID: 18346095
DOI: 10.1111/j.1467-7652.2008.00330.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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