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Production of a monoclonal antibody in plants with a humanized <i>N</i>‐glycosylation pattern

1 Jul 2007

Abstract excerpt

In recent years, plants have become an attractive alternative for the production of recombinant proteins. However, their inability to perform authentic mammalian N-glycosylation may cause limitations for the production of therapeutics. A major concern is the presence of beta1,2-xylose and core alpha1,3-fucose residues on complex N-linked glycans, as these N-glycan epitopes are immunogenic in mammals. In our...

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PMID: 17678502
DOI: 10.1111/j.1467-7652.2007.00273.x

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Production of a monoclonal antibody in plants with a humanized <i>N</i>‐glycosylation patternPMID 17678502Read ↗

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