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Article

The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF2.

Cardiovascular research - 1 Sept 2009

Kuratomi Shinobu, Ohmori Yoko, Ito Masayuki, Shimazaki Kuniko, Muramatsu Shin-Ichi, Mizukami Hiroaki, Uosaki Hideki, Yamashita Jun K, Arai Yuji, Kuwahara Koichiro, Takano Makoto

Abstract excerpt

AIMS: Hcn4, which encodes the hyperpolarization-activated, cyclic nucleotide-sensitive channel (I(h)), is a well-established marker of the cardiac sino-atrial node. We aimed to identify cis-elements in the genomic locus of the Hcn4 gene that regulate the transcription of Hcn4. METHODS AND RESULTS: We screened evolutionarily conserved non-coding sequences (CNSs) that are often involved in the regulation of gene...

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Share to Enhancer Elements, Genetic
Share to Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MEF2 Transcription Factors

Share to Myocytes, Cardiac

Share to Myogenic Regulatory Factors

Share to Potassium Channels

Share to Transcription Factor AP-1

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Source

Identifiers

PMID: 19477969
DOI: 10.1093/cvr/cvp171

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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