Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma.

doi:10.1158/1078-0432.CCR-14-1959

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Article

Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2015

O'Leary Brianne R, Fath Melissa A, Bellizzi Andrew M, Hrabe Jennifer E, Button Anna M, Allen Bryan G, Case Adam J, Altekruse Sean, Wagner Brett A, Buettner Garry R, Lynch Charles F, Hernandez Brenda Y, Cozen Wendy, Beardsley Robert A, Keene Jeffery, Henry Michael D, Domann Frederick E, Spitz Douglas R, Mezhir James J

Abstract excerpt

PURPOSE: Pancreatic ductal adenocarcinoma (PDA) cells are known to produce excessive amounts of reactive oxygen species (ROS), particularly superoxide, which may contribute to the aggressive and refractory nature of this disease. Extracellular superoxide dismutase (EcSOD) is an antioxidant enzyme that catalyzes the dismutation of superoxide in the extracellular environment. This study tests the hypothesis that...

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Identifiers

PMID: 25634994
DOI: 10.1158/1078-0432.CCR-14-1959
PMCID: PMC4383686

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SOD3

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