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Tbx1 and Brn4regulate retinoic acid metabolic genes during cochlear morphogenesis

29 May 2009

Abstract excerpt

BACKGROUND: In vertebrates, the inner ear is comprised of the cochlea and vestibular system, which develop from the otic vesicle. This process is regulated via inductive interactions from surrounding tissues. Tbx1, the gene responsible for velo-cardio-facial syndrome/DiGeorge syndrome in humans, is required for ear development in mice. Tbx1 is expressed in the otic epithelium and adjacent periotic mesenchyme...

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PMID: 19476657
DOI: 10.1186/1471-213x-9-31

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Related research

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Tbx1 and Brn4regulate retinoic acid metabolic genes during cochlear morphogenesisPMID 19476657Read ↗

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dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activity.Semantic proximity Read ↗

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Retinoic acid production, regulation and containment through Zic1, Pitx2c and Cyp26c1 control cranial placode specification.Semantic proximity Read ↗

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