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Article

Tbx1 is required for proper neural crest migration and to stabilize spatial patterns during middle and inner ear development.

Mechanisms of development - 1 Feb 2005

Moraes Filipa, Nóvoa Ana, Jerome-Majewska Loydie A, Papaioannou Virginia E, Mallo Moisés

Abstract excerpt

Tbx1 belongs to the family of T-box containing transcription factors. In humans, TBX1 is implicated in the etiology of the DiGeorge syndrome. Inactivation of the Tbx1 gene in mice produces a variety of malformations including abnormal branching of the heart outflow tract, deficiencies in the branchial arch derivatives, agenesis of pharyngeal glands and abnormal development of the auditory system. We analyze here...

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Source

Identifiers

PMID: 15652707
DOI: 10.1016/j.mod.2004.10.004

Genes

TBX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Tbx1 is required for proper neural crest migration and to stabilize spatial patterns during middle and inner ear development.PMID 15652707Read ↗

TBX1 is required for inner ear morphogenesis.Semantic proximity Read ↗

Tbx1 regulates population, proliferation and cell fate determination of otic epithelial cells.Semantic proximity Read ↗

Tissue-specific roles of Tbx1 in the development of the outer, middle and inner ear, defective in 22q11DS patients.Semantic proximity Read ↗

Tbx1 and Brn4regulate retinoic acid metabolic genes during cochlear morphogenesisSemantic proximity Read ↗

Tbx1 mutation causes multiple cardiovascular defects and disrupts neural crest and cranial nerve migratory pathways.Semantic proximity Read ↗

Canonical Wnt signaling modulates <i>Tbx1</i>, <i>Eya1</i>, and <i>Six1</i> expression, restricting neurogenesis in the otic vesicleSemantic proximity Read ↗

Timed mutation and cell-fate mapping reveal reiterated roles of Tbx1 during embryogenesis, and a crucial function during segmentation of the pharyngeal system via regulation of endoderm expansion.Semantic proximity Read ↗

Tbx1 is required autonomously for cell survival and fate in the pharyngeal core mesoderm to form the muscles of masticationSemantic proximity Read ↗

Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations.Semantic proximity Read ↗

Eya1 acts upstream of Tbx1, Neurogenin 1, NeuroD and the neurotrophins BDNF and NT-3 during inner ear development.Semantic proximity Read ↗

Identification of a Tbx1/Tbx2/Tbx3 genetic pathway governing pharyngeal and arterial pole morphogenesis.Semantic proximity Read ↗

Tbx1, a DiGeorge Syndrome Candidate Gene, Is Regulated by Sonic Hedgehog during Pharyngeal Arch DevelopmentSemantic proximity Read ↗

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