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Article

Tbx1 regulates population, proliferation and cell fate determination of otic epithelial cells.

Developmental biology - 15 Feb 2007

Xu Huansheng, Viola Antonella, Zhang Zhen, Gerken Claudia P, Lindsay-Illingworth Elizabeth A, Baldini Antonio

Abstract excerpt

The T-box transcription factor Tbx1 is required for inner ear morphogenesis. Tbx1 null mutants have a small otocyst that fails to grow and remodel and does not give rise to the vestibular and cochlear apparata. Here we show that Tbx1 expression-driven cell tracing identifies a population of otic epithelial cells that contributes to most of the otocyst. Tbx1 is essential for the contribution of this population to...

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Identifiers

PMID: 17074316
DOI: 10.1016/j.ydbio.2006.10.002
PMCID: PMC1850623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Tbx1 regulates population, proliferation and cell fate determination of otic epithelial cells.PMID 17074316Read ↗

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