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Epidemiological Evidence for the Role of the Hemoglobin Receptor, HmbR, in Meningococcal Virulence

29 May 2009

Abstract excerpt

The distribution of the hemoglobin receptor gene (hmbR) was investigated among disease and carriage Neisseria meningitidis isolates, revealing that the gene was detected at a significantly higher frequency among disease isolates than among carriage isolates. In isolates without hmbR, the locus was occupied by the cassettes exl2 or exl3 or by a "pseudo hmbR" gene, designated exl4. The hmbR locus exhibited...

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PMID: 19476432
DOI: 10.1086/599377

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