Investigation into the Antigenic Properties and Contributions to Growth in Blood of the Meningococcal Haemoglobin Receptors, HpuAB and HmbR.

doi:10.1371/journal.pone.0133855

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Article

Investigation into the Antigenic Properties and Contributions to Growth in Blood of the Meningococcal Haemoglobin Receptors, HpuAB and HmbR.

PloS one - 1 Jan 2015

Bidmos Fadil A, Chan Hannah, Praekelt Uta, Tauseef Isfahan, Ali Youssif M, Kaczmarski Edward B, Feavers Ian, Bayliss Christopher D

Abstract excerpt

Acquisition of iron from host complexes is mediated by four surface-located receptors of Neisseria meningitidis. The HmbR protein and heterodimeric HpuAB complex bind to haemoglobin whilst TbpBA and LbpBA bind iron-loaded transferrin and lactoferrin complexes, respectively. The haemoglobin receptors are unevenly distributed; disease-causing meningococcal isolates encode HmbR or both receptors while strains with...

Topics

Animals
Antibodies, Bacterial
Antigens, Bacterial
Bacteremia
Bacterial Outer Membrane Proteins
Bacterial Proteins
Carrier Proteins
Epitopes
Gene Knockout Techniques
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immune Sera

Iron

Meningitis, Meningococcal

Mice

Mutation

Neisseria meningitidis

Receptors, Cell Surface

Source

Open in PubMed Open full text

Identifiers

PMID: 26208277
DOI: 10.1371/journal.pone.0133855
PMCID: PMC4514712

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