Article
Genetic diversity and levels of expression of factor H binding protein among carriage isolates of Neisseria meningitidis.
PloS one - 1 Jan 2014
Lemée Ludovic, Hong Eva, Etienne Manuel, Deghmane Ala-Eddine, Delbos Valérie, Terrade Aude, Berthelot Gilles, Caron Francois, Taha Muhamed-Kheir
Abstract excerpt
The prevention of meningococcal disease may be improved by recombinant vaccines such as 4CMenB and rLP2086 that target the factor H binding protein (fHbp), an immunogenic surface component of Neisseria meningitidis present as one of three variants. Whether such vaccines decrease carriage of invasive isolates and thus induce herd immunity is unknown. We analyzed the genetic diversity and levels of expression of...
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