Article
Identification of functionally important regions of a haemoglobin receptor from Neisseria meningitidis.
Microbiology (Reading, England) - 1 Dec 2003
Perkins-Balding D, Baer M T, Stojiljkovic I
Abstract excerpt
The HmbR outer-membrane receptor enables Neisseria meningitidis to use haemoglobin (Hb) as a source of iron. This protein functions by binding Hb, removing haem from it, and releasing the haem into the periplasm. Functionally important HmbR receptor domains were discerned using a series of HmbR deletions and site-directed mutations. Mutations exhibiting similar defective phenotypes in N. meningitidis fell into...
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