Article
HmbR, a hemoglobin-binding outer membrane protein of Neisseria meningitidis, undergoes phase variation.
Journal of bacteriology - 1 Apr 1999
Richardson A R, Stojiljkovic I
Abstract excerpt
Neisseria meningitidis uses hemoglobin (Hb) as an iron source via two TonB-dependent outer membrane receptors, HmbR and HpuB. Analysis of 25 epidemiologically unrelated clinical isolates from serogroups A, B, C, and Y revealed that 64% strains possessed both Hb receptor genes. Examination of the hmbR expression pattern in strains in which the hpuB gene was genetically inactivated revealed two distinct Hb...
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