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Article

Differentiation-dependent interactions between RUNX-1 and FLI-1 during megakaryocyte development.

Molecular and cellular biology - 1 Aug 2009

Huang Hui, Yu Ming, Akie Thomas E, Moran Tyler B, Woo Andrew J, Tu Nathan, Waldon Zachary, Lin Yin Yin, Steen Hanno, Cantor Alan B

Abstract excerpt

The transcription factor RUNX-1 plays a key role in megakaryocyte differentiation and is mutated in cases of myelodysplastic syndrome and leukemia. In this study, we purified RUNX-1-containing multiprotein complexes from phorbol ester-induced L8057 murine megakaryoblastic cells and identified the ets transcription factor FLI-1 as a novel in vivo-associated factor. The interaction occurs via direct protein-protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19470763
DOI: 10.1128/MCB.00090-09
PMCID: PMC2715817

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Differentiation-dependent interactions between RUNX-1 and FLI-1 during megakaryocyte development.PMID 19470763Read ↗

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