Article
Association of interleukin-18 gene polymorphisms with hepatitis B virus clearance.
Digestive diseases and sciences - 1 Apr 2010
Cheong Jae Youn, Cho Sung Won, Oh Bermseok, Kimm Kuchan, Lee Kee Myung, Shin Sung Jae, Lee Jung A, Park Byung Lae, Cheong Hyun Sub, Shin Hyoung Doo, Cho Bo Young, Kim Jin Hong
Abstract excerpt
The outcome of hepatitis B virus (HBV) infection can be affected by host immune factors. Interleukin-18 (IL-18) was originally discovered as an interferon-gamma-inducing factor and plays a critical role in immune response. We assessed the association between the clearance of HBV infection and single-nucleotide polymorphisms (SNPs) in the IL-18 gene. Between March 2002 and December 2004, a total of 1,050 Korean...
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