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Article

Regulatory polymorphisms in the interleukin-18 promoter are associated with hepatitis C virus clearance.

The Journal of infectious diseases - 15 Oct 2008

An Ping, Thio Chloe L, Kirk Gregory D, Donfield Sharyne, Goedert James J, Winkler Cheryl A

Abstract excerpt

The immune response is critical in determining the outcome of hepatitis C virus (HCV) infection. Interleukin (IL)-18 is a pivotal mediator of the Th1/Th2-driven immune response. Two IL-18 promoter polymorphisms (-607C/A and -137G/C) and their haplotypes were known to affect IL-18 expression. We examined the role played by these polymorphisms in determining HCV clearance or persistence. Genotyping was performed...

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Identifiers

PMID: 18781864
DOI: 10.1086/592047
PMCID: PMC2674361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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