Article
Association of TNF-alpha promoter polymorphisms with the clearance of hepatitis B virus infection.
Human molecular genetics - 1 Oct 2003
Kim Yoon Jun, Lee Hyo-Suk, Yoon Jung-Hwan, Kim Chung Yong, Park Myoung Hee, Kim Lyoung Hyo, Park Byung Lae, Shin Hyoung Doo
Abstract excerpt
The mechanisms underlying the resolution of hepatitis B virus (HBV) infection remain undetermined. Tumor necrosis factor-alpha (TNF-alpha) plays a pivotal role in host immune response to HBV, and the capacity for cytokine production in individuals has a major genetic component. The aim of this study was to examine whether TNF-alpha promotor polymorphisms are associated with the clearance of HBV infection. A total...
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