Article
High-resolution melting analysis for a reliable and two-step scanning of mutations in the tyrosine kinase domain of the chimerical bcr-abl gene.
International journal of hematology - 1 Jul 2009
Doi Yuko, Sasaki Daisuke, Terada Chiharu, Mori Sayaka, Tsuruda Kazuto, Matsuo Emi, Miyazaki Yasushi, Nagai Kazuhiro, Hasegawa Hiroo, Yanagihara Katsunori, Yamada Yasuaki, Kamihira Shimeru
Abstract excerpt
For relevant imatinib therapy against Philadelphia (Ph)-positive leukemias, it is essential to monitor mutations in the chimerical bcr-abl tyrosine kinase domain (TKD). However, there is no universally acceptable consensus on how to efficiently identify mutations in the target TKD. Recently, high-resolution melting (HRM) technology was developed, which allows gene scanning using an inexpensive generic...
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