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Article

Four-channel asymmetric Real-Time PCR hybridization probe assay: a rapid pre-screening method for critical BCR-ABL kinase domain mutations.

Clinical biochemistry - 1 Mar 2012

Martinez-Serra Jordi, Gutiérrez Antonio, Marcús Toni F, Soverini Simona, Amat Juan Carlos, Navarro-Palou María, Ros Teresa, Bex Teresa, Ballester Carmen, Bauça Josep Miquel, SanFelix Sara, Novo Andrés, Vidal Carmen, Santos Carmen, Besalduch Joan

Abstract excerpt

OBJECTIVES: Within the laboratory protocols, used for the study of BCR-ABL resistance mutations in chronic myeloid leukemia patients treated with Imatinib, direct sequencing remains the reference method. Since the incidence of patients with a mutation-related loss of response is not very high, it is very useful in the routine laboratory to perform a fast pre-screening method. DESIGN AND METHODS: With this in...

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Identifiers

PMID: 22266405
DOI: 10.1016/j.clinbiochem.2011.12.026

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BCR

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