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Article

High-resolution melt curve analysis: initial screening for mutations in BCR-ABL kinase domain.

Leukemia research - 1 Aug 2008

Poláková Katerina Machová, Lopotová Tereza, Klamová Hana, Moravcová Jana

Abstract excerpt

Mutations in BCR-ABL kinase domain are associated with resistance to tyrosine kinase inhibitors in some patients with chronic myeloid leukemia. Therefore, mutation detection becomes essential in such patients. We aimed to apply high-resolution melt curve analysis (HRM) for a rapid screening prior to sequencing to select only mutation positive samples. One hundred and one samples with different mutations and...

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Source

Identifiers

PMID: 18308387
DOI: 10.1016/j.leukres.2008.01.010

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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