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Article

Rapid detection of the R389G polymorphism of ADRB1 by real time PCR using fluorescence resonance energy transfer.

Clinical laboratory - 1 Jan 2009

Sauer Matthias, Tews Julia, Schwarzer Michael, Seeburger Joerg, Adams Volker, Falk Volkmar, Dhein Stefan, Mohr Friedrich-Wilhelm

Abstract excerpt

The beta1-adrenoceptor plays a crucial role in the regulation of myocardial contractility and heart rate. A functionally important polymorphism at codon 389 has been associated with heart failure and hypertension. The conventional method of detecting this polymorphism is a PCR-assay followed by digestion with specific restriction enzyme (PCR-RFLP) polymorphism. We aimed to establish an alternative, fast...

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Share to Fluorescence Resonance Energy Transfer
Share to Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymerase Chain Reaction

Share to Polymorphism, Genetic

Share to Polymorphism, Restriction Fragment Length

Share to Receptors, Adrenergic, beta-1

Share to Reproducibility of Results

Share to Sequence Analysis, DNA

Source

Identifiers

PMID: 19462935

Genes

ADRB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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