Article
No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population.
Journal of human genetics - 1 Aug 2009
Otowa Takeshi, Shimada Takafumi, Kawamura Yoshiya, Liu Xiaoxi, Inoue Ken, Sugaya Nagisa, Minato Takanobu, Nakagami Ryoichi, Tochigi Mamoru, Umekage Tadashi, Kasai Kiyoto, Kato Nobumasa, Tanii Hisashi, Okazaki Yuji, Kaiya Hisanobu, Sasaki Tsukasa
Abstract excerpt
Panic disorder (PD) is a severe and chronic psychiatric disorder, with significant genetic components in the etiology. Brain-derived neurotrophic factor (BDNF) gene, which has regulatory effects on neurotransmitter systems such as serotonin and dopamine, is a candidate for susceptibility locus of PD. This study investigated three single-nucleotide polymorphisms (SNPs) of BDNF (rs6265 (Val66Met), rs11030104 and...
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