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Prion protein gene (PRNP) variation in German and Danish cervids.

Veterinary research - 2 Aug 2024

Ernst Sonja, Piestrzyńska-Kajtoch Agata, Gethmann Jörn, Natonek-Wiśniewska Małgorzata, Sadeghi Balal, Polak Miroslaw P, Keller Markus, Gavier-Widén Dolores, Moazami-Goudarzi Katayoun, Houston Fiona, Groschup Martin H, Fast Christine

Abstract excerpt

The structure of cellular prion proteins encoded by the prion protein gene (PRNP) impacts susceptibility to transmissible spongiform encephalopathies, including chronic wasting disease (CWD) in deer. The recent emergence of CWD in Northern European reindeer (Rangifer tarandus), moose (Alces alces alces) and red deer (Cervus elaphus), in parallel with the outbreak in North America, gives reason to investigate PRNP...

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Identifiers

PMID: 39095901
DOI: 10.1186/s13567-024-01340-8
PMCID: PMC11297704

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