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Restriction of Equine Infectious Anemia Virus by Equine APOBEC3 Cytidine Deaminases

21 May 2009

Abstract excerpt

The mammalian APOBEC3 (A3) proteins comprise a multigene family of cytidine deaminases that act as potent inhibitors of retroviruses and retrotransposons. The A3 locus on the chromosome 28 of the horse genome contains multiple A3 genes: two copies of A3Z1, five copies of A3Z2, and a single copy of A3Z3, indicating a complex evolution of multiple gene duplications. We have cloned and analyzed for expression the...

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PMID: 19458006
DOI: 10.1128/jvi.00015-09

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