Comparable studies of immunostimulating activities<i>in vitro</i>among<i>Mycobacterium bovis</i>bacillus Calmette-Guérin (BCG) substrains

Abstract excerpt

During the serial passage of Mycobacterium bovis bacillus Calmette-Guérin (BCG) in different countries after initial seed distribution from the Pasteur Institute, specific insertions and deletions in the genome among BCG substrains were observed and speculated to result in differences in immunological activities. 'Early-shared strains' of BCG (Russia, Moreau, Japan, Sweden, Birkhaug), distributed by the Pasteur...

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