Article
Copper(I)-mediated protein-protein interactions result from suboptimal interaction surfaces.
The Biochemical journal - 29 Jul 2009
Banci Lucia, Bertini Ivano, Calderone Vito, Della-Malva Nunzia, Felli Isabella C, Neri Sara, Pavelkova Anna, Rosato Antonio
Abstract excerpt
The homoeostasis of metal ions in cells is the result of the contribution of several cellular pathways that involve transient, often weak, protein-protein interactions. Metal transfer typically implies the formation of adducts where the metal itself acts as a bridge between proteins, by co-ordinating residues of both interacting partners. In the present study we address the interaction between the human...
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