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Article

Human copper transporter ATP7B (Wilson disease protein) forms stable dimers in vitro and in cells.

The Journal of biological chemistry - 17 Nov 2017

Jayakanthan Samuel, Braiterman Lelita T, Hasan Nesrin M, Unger Vinzenz M, Lutsenko Svetlana

Abstract excerpt

ATP7B is a copper-transporting P1B-type ATPase (Cu-ATPase) with an essential role in human physiology. Mutations in ATP7B cause the potentially fatal Wilson disease, and changes in ATP7B expression are observed in several cancers. Despite its physiologic importance, the biochemical information about ATP7B remains limited because of a complex multidomain organization of the protein. By analogy with the better...

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Identifiers

PMID: 28842499
DOI: 10.1074/jbc.M117.807263
PMCID: PMC5704462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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