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Article

The influence of protein folding on the copper affinities of trafficking and target sites.

Dalton transactions (Cambridge, England : 2003) - 7 Mar 2013

Allen Stephen, Badarau Adriana, Dennison Christopher

Abstract excerpt

The relative influence of protein unfolding on the Cu(I) affinity of trafficking and target sites for copper has been determined. For the copper metallochaperone Atx1 from Synechocystis PCC 6803 (a cyanobacterium), Saccharomyces cerevisiae and humans unfolding in urea results in a decrease in the Cu(I) affinity from (4-5) × 10(17) M(-1) to (1-3) × 10(16) M(-1) at pH 7. The affinities of the unfolded Atx1s are...

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Identifiers

PMID: 23169585
DOI: 10.1039/c2dt32166a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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