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Article

Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Oct 2009

Freedman Barry I, Bowden Donald W, Ziegler Julie T, Langefeld Carl D, Lehtinen Allison B, Rudock Megan E, Lenchik Leon, Hruska Keith A, Register Thomas C, Carr J Jeffrey

Abstract excerpt

Inverse relationships have been observed between BMD and vascular calcification (VC), suggesting an underlying metabolic pathway linking these processes. Bone morphogenetic proteins (BMPs) are potential candidate genes that may mediate this relationship. Four single nucleotide polymorphisms (SNPs) in the BMP2 gene, 2 SNPs in BMP4, and 16 SNPs in BMP7 were tested for association with measures of VC using CT...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19453255
DOI: 10.1359/jbmr.090501
PMCID: PMC2743282

Genes

BMP7
BMP2
BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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