Article
IL-10 promotor haplotypes associated with susceptibility to and severity of bacterial corneal ulcers.
Experimental eye research - 1 Jun 2009
Keijser S, Kurreeman F A S, de Keizer R J W, Dogterom-Ballering H, van der Lelij A, Jager M J, Nibbering P H
Abstract excerpt
Interleukin-10 plays an important role in modulating inflammation and antimicrobial defences. In animal models for bacterial corneal ulcers, high IL-10 levels were associated with a better clinical outcome. We investigated whether IL-10 promotor haplotypes, known to determine IL-10 expression in vitro, are associated with susceptibility to and/or clinical outcome of bacterial corneal ulcers in patients. IL-10...
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