Article
Genetic polymorphisms in CYP1A1, CYP1B1, COMT, GSTP1 and NAT2 genes and association with bladder cancer risk in a French cohort.
Anticancer research - 1 May 2009
Fontana Luc, Delort Laetitia, Joumard Laurie, Rabiau Nadege, Bosviel Remy, Satih Samir, Guy Laurent, Boiteux Jean-Paul, Bignon Yves-Jean, Chamoux Alain, Bernard-Gallon Dominique J
Abstract excerpt
UNLABELLED: Tobacco smoking and environmental exposures are the main known risk factors for bladder cancer (BC) via exposure to chemical carcinogens. Genetic differences in the metabolism of chemicals have been suggested to be associated with individual susceptibility to BC. Polymorphisms in genes coding to metabolising enzymes, resulting in variation of carcinogen detoxification efficiency, may therefore change...
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