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Article

Discovery of a novel genetic variant in the N-acetyltransferase2 (NAT2) gene that is associated with bladder cancer risk.

Acta biochimica Polonica - 18 Aug 2023

Elsalem Lina, Al Shatnawi Ahmad, A Alfaqih Mahmoud, Alshoh Ayat, Al Demour Saddam, Al-Daghmin Ali, Halalsheh Omar, Kheirallah Khalid, Ahram Mamoun

Abstract excerpt

Smoking is a main risk factor for bladder cancer (BC). NAT2 is a drug-metabolizing enzyme that catalyses the detoxification of many xenobiotics and carcinogens. Single nucleotide polymorphism (SNP) in NAT2 results in different acetylation phenotypes (fast, intermediate or slow). Certain NAT2 SNPs were associated with BC and/or modified the association of BC with smoking. However, limited evidence is available...

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PMID: 37595067
DOI: 10.18388/abp.2020_6590

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