Article
SNP-based prediction of the human germ cell methylation landscape.
Genomics - 1 May 2009
Xie Hehuang, Wang Min, Bischof Jared, Bonaldo Maria de Fatima, Soares Marcelo Bento
Abstract excerpt
Base substitution occurs at a high rate at CpG dinucleotides due to the frequent methylation of CpG and the deamination of methylated cytosine to thymine. If these substitutions occur in germ cells, they constitute a heritable mutation that may eventually rise to polymorphic frequencies, hence resulting in a SNP that is methylation associated. In this study, we sought to identify clusters of methylation...
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