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Article

Prospective identification of malaria parasite genes under balancing selection.

PloS one - 1 Jan 2009

Tetteh Kevin K A, Stewart Lindsay B, Ochola Lynette Isabella, Amambua-Ngwa Alfred, Thomas Alan W, Marsh Kevin, Weedall Gareth D, Conway David J

Abstract excerpt

BACKGROUND: Endemic human pathogens are subject to strong immune selection, and interrogation of pathogen genome variation for signatures of balancing selection can identify important target antigens. Several major antigen genes in the malaria parasite Plasmodium falciparum have shown such signatures in polymorphism-versus-divergence indices (comparing with the chimpanzee parasite P. reichenowi), and in allele...

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Identifiers

PMID: 19440377
DOI: 10.1371/journal.pone.0005568
PMCID: PMC2679211

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Source receipt: pubmed, retrieved 7 Sept 2026.

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