Article
Rapamycin impairs UV induction of mutant-p53 overexpressing cell clusters without affecting tumor onset.
International journal of cancer - 15 Sept 2012
Voskamp P, Bodmann C A, Rebel H G, Koehl G E, Tensen C P, Bouwes Bavinck J N, El Ghalbzouri A, Van Kranen H J, Willemze R, Geissler E K, De Gruijl F R
Abstract excerpt
Because of its antitumor effect, the immunosuppressant rapamycin holds great promise for organ transplant recipients in that it may lower their cancer risk. In a mouse model, we showed previously that rapamycin inhibits the outgrowth of primary skin carcinomas induced by UV radiation. However, the tumors that did grow out showed an altered p53 mutation spectrum. Here, we investigated whether this shift in p53...
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