Article
Genome wide analysis and clinical correlation of chromosomal and transcriptional mutations in cancers of the biliary tract.
Journal of experimental & clinical cancer research : CR - 12 May 2009
Miller George, Socci Nicholas D, Dhall Deepti, D'Angelica Michael, DeMatteo Ronald P, Allen Peter J, Singh Bhuvanesh, Fong Yuman, Blumgart Leslie H, Klimstra David S, Jarnagin William R
Abstract excerpt
BACKGROUND: The pathogenesis of biliary cancers is ill-defined. This study investigates changes in gene expression and copy number in biliary cancers and correlates these changes with anatomical site of origin, histopathology and outcome. METHODS: We performed gene expression and CGH analysis on 34 biliary tract cancer specimens. Results were confirmed by RT-PCR. Clinical-pathologic correlation was made using...
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