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Article

In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug.

Investigational new drugs - 1 Jan 2006

Brandon Esther F A, Sparidans Rolf W, Guijt Kees-Jan, Löwenthal Sjoerd, Meijerman Irma, Beijnen Jos H, Schellens Jan H M

Abstract excerpt

ET-743 is a potent marine anti-cancer drug and is currently being investigated in phase I and II clinical trials, e.g. in combination with other anti-cancer agents. To assess the biotransformation and CYP reaction phenotype and their potential implications for human pharmacology and toxicology, t...

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Identifiers

PMID: 16379042
DOI: 10.1007/s10637-005-4538-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16379042-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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