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Article

Matrix metalloproteinase-9 controls NMDA receptor surface diffusion through integrin beta1 signaling.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 May 2009

Michaluk Piotr, Mikasova Lenka, Groc Laurent, Frischknecht Renato, Choquet Daniel, Kaczmarek Leszek

Abstract excerpt

Matrix metalloproteinase-9 (MMP-9) has emerged as a physiological regulator of NMDA receptor (NMDAR)-dependent synaptic plasticity and memory. The pathways by which MMP-9 affects NMDAR signaling remain, however, elusive. Using single quantum dot tracking, we demonstrate that MMP-9 enzymatic activity increases NR1-NMDAR surface trafficking but has no influence on AMPA receptor mobility. The mechanism of MMP-9...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19420267
DOI: 10.1523/JNEUROSCI.5346-08.2009
PMCID: PMC6665240

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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