Article
Diversity of pneumococcal surface protein A (PspA) among prevalent clones in Spain.
BMC microbiology - 6 May 2009
Rolo Dora, Ardanuy Carmen, Fleites Ana, Martín Rogelio, Liñares Josefina
Abstract excerpt
BACKGROUND: PspA is recognized as a major pneumococcal virulence factor and a possible vaccine candidate. The aim of this study was to analyze the PspA family and clade distribution among 112 Spanish pneumococci representatives of dominant clones among patients with invasive disease (n = 66) and nasopharyngeal healthy carriage in children (n = 46). RESULTS: PspA family 2 was predominant among invasive (63.6%) and...
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