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Article

Genetic diversity of pneumococcal surface protein A (PspA) in paediatric isolates of non-conjugate vaccine serotypes in Japan.

Journal of medical microbiology - 1 Aug 2018

Kawaguchiya Mitsuyo, Urushibara Noriko, Aung Meiji Soe, Morimoto Shigeo, Ito Masahiko, Kudo Kenji, Kobayashi Nobumichi

Abstract excerpt

PURPOSE: Among the pneumococcal proteins, pneumococcal surface protein A (PspA) is considered the most promising candidate for a serotype-independent vaccine. This study aimed to investigate the serotype, genetic diversity of PspA, lineage (genotype) and drug resistance traits of pneumococcal isolates from paediatric patients. METHODOLOGY: A total of 678 non-invasive pneumococcal isolates obtained from June to...

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PMID: 29927374
DOI: 10.1099/jmm.0.000775

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