Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diversity of PspA: mosaic genes and evidence for past recombination in Streptococcus pneumoniae.

Infection and immunity - 1 Oct 2000

Hollingshead S K, Becker R, Briles D E

Abstract excerpt

Pneumococcal surface protein A (PspA) is a serologically variable protein of Streptococcus pneumoniae. Twenty-four diverse alleles of the pspA gene were sequenced to investigate the genetic basis for serologic diversity and to evaluate the potential of diversity to have an impact on PspA's use in human vaccination. The 24 pspA gene sequences from unrelated strains revealed two major allelic types, termed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Bacterial Proteins
Share to Pneumococcal Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Recombination, Genetic

Share to Selection, Genetic

Share to Sequence Alignment

Share to Sequence Analysis, DNA

Share to Streptococcus pneumoniae

Source

Open in PubMed Open full text

Identifiers

PMID: 10992499
DOI: 10.1128/IAI.68.10.5889-5900.2000
PMCID: PMC101551

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diversity of PspA: mosaic genes and evidence for past recombination in Streptococcus pneumoniae.PMID 10992499Read ↗

Genetic diversity of pneumococcal surface protein A in invasive pneumococcal isolates from Korean children, 1991-2016.Semantic proximity Read ↗

Genetic diversity of PspA types among nasopharyngeal isolates collected during an ongoing surveillance study of children in Brazil.Semantic proximity Read ↗

Genetic diversity of pneumococcal surface protein A of Streptococcus pneumoniae meningitis in German children.Semantic proximity Read ↗

The diversity of the proline-rich domain of pneumococcal surface protein A (PspA): Potential relevance to a broad-spectrum vaccineSemantic proximity Read ↗

Monitoring the long-term molecular epidemiology of the pneumococcus and detection of potential 'vaccine escape' strains.Semantic proximity Read ↗

Diversity of pneumococcal surface protein A (PspA) among prevalent clones in Spain.Semantic proximity Read ↗

Genetic diversity of pneumococcal surface protein A (PspA) in paediatric isolates of non-conjugate vaccine serotypes in Japan.Semantic proximity Read ↗

Allelic variation in the highly polymorphic locus pspC of Streptococcus pneumoniae.Semantic proximity Read ↗

Phylogenetic distribution of streptococcal superantigen SSA allelic variants provides evidence for horizontal transfer of ssa within Streptococcus pyogenes.Semantic proximity Read ↗

Hyper-recombination, diversity, and antibiotic resistance in pneumococcus.Semantic proximity Read ↗

Pneumococcal Capsule Synthesis Locus cps as Evolutionary Hotspot with Potential to Generate Novel Serotypes by Recombination.Semantic proximity Read ↗

Diversity of pneumococcal surface protein A (PspA) and relation to sequence typing in Streptococcus pneumoniae causing invasive disease in Chinese children.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.